Bio


My name is Chelsey Derderian-LeBlang and I am a neuroscientist specializing in translational studies of neurodegeneration in the central and peripheral nervous systems.  My expertise lie in generating iPSC derived models and using biochemical and advanced imaging techniques to  understand molecular mechanisms underlying neurodegenerative disease. I am passionate about neuroimmunology, and how immune system dysfunction can contribute to the pathogenesis of disease. I defended my dissertation investigating the role of pathologic stress granules in neuroinflammation and the pathogenesis of tauopathy in 2020, earning my PhD in Anatomy & Neurobiology at Boston University School of Medicine. Currently, I am a senior postdoctoral research fellow in the department of Cancer Biology at Dana Farber Cancer Institute (DFCI) and the department of Neurobiology at Harvard Medical School (HMS). I have completed a T32 fellowship  in Cancer Chemical Biology and Metabolism  research fellowship under the mentorship of Rosalind Segal, MD/PhD,  studying molecular mechanisms of axonal degeneration in Chemotherapy Induced Peripheral Neuropathy.  I plan to continue my studies in chemotherapy related toxicity, studying glial contribution to degeneration in the CNS and PNS. 


Publications


Satellite glial contact enhances differentiation and maturation of human iPSC-derived sensory neurons


Chelsey J. LeBlang, Maria F. Pazyra-Murphy, Elizabeth Silagi, Srestha Dasgupta, Marianna Tsolias, Toussaint Miller, Veselina Petrova, Shannon Zhen, Vukasin Jovanovic, David Castellano, Kathryn Gerrish, Pinar Ormanoglu, Carlos Tristan, Ilyas Singec, Clifford J. Woolf, Ozge Tasdemir-Yilmaz, Rosalind A. Segal

Biorxiv, 2024


Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy


C. LeBlang, M. Medalla, N. Nicoletti, Emma C Hays, James Zhao, J. Shattuck, A. Cruz, B. Wolozin, J. Luebke

Frontiers in Neuroscience, 2020


Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo


D. Apicco, Peter E. A. Ash, Brandon F. Maziuk, C. LeBlang, M. Medalla, A. Al Abdullatif, A. Ferragud, Emily Botelho, Heather Ballance, U. Dhawan, S. Boudeau, A. Cruz, Daniel Kashy, Aria Wong, L. Goldberg, N. Yazdani, C. Zhang, C. Ung, Y. Tripodis, N. Kanaan, T. Ikezu, P. Cottone, J. Leszyk, Hu Li, J. Luebke, C. Bryant, B. Wolozin

Nature Neuroscience, 2017

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