My name is Chelsey Derderian-LeBlang and I am a neuroscientist specializing in translational studies of neurodegeneration in the central and peripheral nervous systems. My expertise lie in generating iPSC derived models and using biochemical and advanced imaging techniques to understand molecular mechanisms underlying neurodegenerative disease. I am passionate about neuroimmunology, and how immune system dysfunction can contribute to the pathogenesis of disease. I defended my dissertation investigating the role of pathologic stress granules in neuroinflammation and the pathogenesis of tauopathy in 2020, earning my PhD in Anatomy & Neurobiology at Boston University School of Medicine. Currently, I am a senior postdoctoral research fellow in the department of Cancer Biology at Dana Farber Cancer Institute (DFCI) and the department of Neurobiology at Harvard Medical School (HMS). I have completed a T32 fellowship in Cancer Chemical Biology and Metabolism research fellowship under the mentorship of Rosalind Segal, MD/PhD, studying molecular mechanisms of axonal degeneration in Chemotherapy Induced Peripheral Neuropathy. I plan to continue my studies in chemotherapy related toxicity, studying glial contribution to degeneration in the CNS and PNS.
Publications
Chelsey J. LeBlang, Maria F. Pazyra-Murphy, Elizabeth Silagi, Srestha Dasgupta, Marianna Tsolias, Toussaint Miller, Veselina Petrova, Shannon Zhen, Vukasin Jovanovic, David Castellano, Kathryn Gerrish, Pinar Ormanoglu, Carlos Tristan, Ilyas Singec, Clifford J. Woolf, Ozge Tasdemir-Yilmaz, Rosalind A. Segal
Biorxiv, 2024
Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy
C. LeBlang, M. Medalla, N. Nicoletti, Emma C Hays, James Zhao, J. Shattuck, A. Cruz, B. Wolozin, J. Luebke
Frontiers in Neuroscience, 2020
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
D. Apicco, Peter E. A. Ash, Brandon F. Maziuk, C. LeBlang, M. Medalla, A. Al Abdullatif, A. Ferragud, Emily Botelho, Heather Ballance, U. Dhawan, S. Boudeau, A. Cruz, Daniel Kashy, Aria Wong, L. Goldberg, N. Yazdani, C. Zhang, C. Ung, Y. Tripodis, N. Kanaan, T. Ikezu, P. Cottone, J. Leszyk, Hu Li, J. Luebke, C. Bryant, B. Wolozin
Nature Neuroscience, 2017
